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Research has shown psilocybin to have potential to treat a range of psychiatric and behavioral disorders, although it’s yet to receive FDA approval for anything.

Its potential indications include depression, obsessive-compulsive disorder, quitting smoking, alcohol addiction, cocaine addiction, cluster headachesTrusted Source, and cancer-related or other end-of-life psychological distress.

High-profile initiatives have also popped up in recent months in Denver, Colorado, and Oregon to decriminalize psilocybin mushrooms.

However, experts say they’re unlikely to pass.

Psilocybin mushrooms remain a Schedule I drug according to the Drug Enforcement Administration, meaning they’re classified as having “no currently accepted medical use and a high potential for abuse.”

Other Schedule I drugs include marijuana, MDMA, and LSD.

Yet, despite social stigma and legal red tape, researchers are forging ahead with clinical trials for FDA approval.

Dr. George R. Greer, co-founder and president of the Heffter Research Institute, a non-profit research center that focuses on the therapeutic uses of psychedelics, particularly psilocybin, explains his motivations:

“Our mission is two-fold: one to do research that helps us understand the mind, the brain, how all that works, and number two, to help reduce suffering through therapeutic use of psychedelics.”

The institute is currently focused on two main areas of psilocybin research: addiction and cancer-related psychiatric disorders. Cancer-related psilocybin therapy is considered one of the most promising areas of research for the drug.

However, considering the vast number of potential indications for psilocybin, it’s important to keep in mind that the amount of research also varies widely, from single pilot studies to phase II or III approval trials by the FDA.

Here’s what the current research says about psilocybin treatment for some potential indications.

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